Blood Serum

Taxonomy

• Homo sapiens (Human)
• Bos taurus (Bovine)

Protein

• Alpha-1-antitrypsin / Homo sapiens    P01009
• Immunoglobulin heavy constant alpha 1 / Homo sapiens    P01876
• Apolipoprotein E / Bos taurus    Q03247
• Fetuin-b / Bos taurus    Q58D62
• Fibrinogen beta chain / Bos taurus    P02676
• Insulin-like growth factor II / Bos taurus    P07456
• Inter-alpha-trypsin inhibitor heavy chain h1 / Bos taurus    Q0VCM5
• Inter-alpha-trypsin inhibitor heavy chain h4 / Bos taurus    Q3T052
• Plasma serine protease inhibitor / Bos taurus    Q9N2I2

Source

• Blood Serum (UBERON_0001977)  

Reported structure

• O-Linked / Core 0 / GalNAc

Composition

• HexNAc:1 (avg mass : 221.2103 )

Disease

• Multiple myeloma (DOID:9538)

Reference

• Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis (2021 - Rebeca Kawahara, Anastasia Chernykh, Kathirvel Alagesan, Marshall Bern, Weiqian Cao, Robert J. Chalkley, Kai Cheng, Matthew S. Choo, Nathan Edwards, Radoslav Goldman, Marcus Hoffmann, Yingwei Hu, Yifan Huang, Jin Young Kim, Doron Kletter, Benoit Liquet, Mingqi Liu, Yehia Mechref, Bo Meng, Sriram Neelamegham, Terry Nguyen-Khuong, Jonas Nilsson, Adam Pap, Gun Wook Park, Benjamin L. Parker, Cassandra L. Pegg, Josef M. Penninger, Toan K. Phung, Markus Pioch, Erdmann Rapp, Enes Sakalli, Miloslav Sanda, Benjamin L. Schulz, Nichollas E. Scott, Georgy Sofronov, Johannes Stadlmann, Sergey Y. Vakhrushev, Christina M. Woo, Hung-Yi Wu, Pengyuan Yang, Wantao Ying, Hui Zhang, Yong Zhang, Jingfu Zhao, Joseph Zaia, Stuart M. Haslam, Giuseppe Palmisano, Jong Shin Yoo, Göran Larson, Kai-Hooi Khoo, Katalin F. Medzihradszky, Daniel Kolarich, Nicolle H. Packer, Morten Thaysen-Andersen) / Status : Reviewed
• Affinity enrichment and characterization of mucin core-1 type glycopeptides from bovine serum (2009 - Darula Z, Medzihradszky KF.) / Status : Reviewed
• O-linked oligosaccharides from human serum immunoglobulin A1. (1989 - Field M, Dwek R, Edge C, Rademacher T) / Status : Reviewed
• Structure of the carbohydrate units of IgA1 immunoglobulin. II. Stucture of the O-glycosidically linked oligosaccharide units. (1974 - Baenziger J, Kornfeld S) / Status : Reviewed

Reported glycosite

• Alpha-1-antitrypsin / Homo sapiens
  •        Thr-109
• Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •        Undefined site
  •        Ser-105
• Apolipoprotein E / Bos taurus
  •        Thr-32
  •        Ser-310
• Fetuin-b / Bos taurus
  •        Thr-292
• Fibrinogen beta chain / Bos taurus
  •        Thr-4
• Insulin-like growth factor II / Bos taurus
  •        Thr-106
• Inter-alpha-trypsin inhibitor heavy chain h1 / Bos taurus
  •        Ser-643
• Inter-alpha-trypsin inhibitor heavy chain h4 / Bos taurus
  •        Ser-683
  •        Thr-705
• Plasma serine protease inhibitor / Bos taurus
  •        Thr-36

Mass spectrometry observed peptide

• ADTHDEILEGLNFNLTEIPEAQIHEGFQELLR (32aa)
  •    P01009    Thr-109     Alpha-1-antitrypsin / Homo sapiens