Diabetes Mellitus, Non-insulin dependent

Taxonomy

• Homo sapiens (Human)

Protein

• Forkhead box protein O1 / Homo sapiens    Q12778

Source

• Liver (UBERON_0002107)  

Reported structure

• O-Linked / O-GlcNAc / GlcNAc(b

Composition

• HexNAc:1 (avg mass : 221.2103 )

Disease

• Diabetes Mellitus, Non-insulin dependent (DOID:9352)

Reference

• O-GlcNAc Regulates FoxO Activation in Response to Glucose (2008 - Michael P Housley, Joseph T Rodgers, Namrata D Udeshi, Timothy J Kelly, Jeffrey Shabanowitz, Donald F Hunt, Pere Puigserver, Gerald W Hart) / Status : Reviewed

Reported glycosite

• Forkhead box protein O1 / Homo sapiens
  •        Thr-317
  •        Ser-550
  •        Thr-648
  •        Ser-654

Mass spectrometry observed peptide

• STFRPRTSSNASTISGRLSP (20aa)
  •    Q12778    Thr-317     Forkhead box protein O1 / Homo sapiens
• PHTSGMNRL (9aa)
  •    Q12778    Ser-550     Forkhead box protein O1 / Homo sapiens
• FPHSVKTTTHSWVSG (15aa)
  •    Q12778    Thr-648     Forkhead box protein O1 / Homo sapiens
  •    Q12778    Ser-654     Forkhead box protein O1 / Homo sapiens