Immunoglobulin epsilon chain c region

Taxonomy

• Homo sapiens (Human)

Protein

• Immunoglobulin epsilon chain c region / Homo sapiens    P01854

Source

• Blood Plasma (UBERON_0001969)  
• Blood Serum (UBERON_0001977)  
• HEK293T (CVCL_0063)  

Reported structure

• N-Linked / Complex / Structure 1850
• N-Linked / Complex / Structure 1994
• N-Linked / Complex / Structure 1497
• N-Linked / Complex / Structure 2643
• N-Linked / Complex / Structure 2011
• N-Linked / Complex / Structure 2719
• N-Linked / Complex / Structure 9835
• N-Linked / Complex / Structure 10128
• N-Linked / Complex / Structure 10309
• N-Linked / Complex / Gal(?1-?)GlcNAc(?1-?)Man(a1-3)[Gal(?1-?)GlcNAc(?1-?)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / Structure 2888
• N-Linked / Complex / Structure 10244
• N-Linked / Complex / Gal(?1-?)GlcNAc(?1-?)Man(a1-3)[Gal(?1-?)GlcNAc(?1-?)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Structure 10169
• N-Linked / Complex / Structure 10199
• N-Linked / Complex / Structure 10207
• N-Linked / Complex / Structure 10216
• N-Linked / Complex / Structure 10310
• N-Linked / Complex / Structure 1147
• N-Linked / Complex / Structure 10159
• N-Linked / Complex / Structure 1344
• N-Linked / Complex / Structure 10246
• N-Linked / Complex / Structure 10206
• N-Linked / Complex / Structure 3446
• N-Linked / Complex / Structure 10148
• N-Linked / Complex / Structure 1523
• N-Linked / Complex / NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Structure 10167
• N-Linked / Complex / Structure 10186
• N-Linked / Complex / Structure 10197
• N-Linked / Complex / Structure 10293
• N-Linked / Complex / Structure 10174
• N-Linked / Complex / Structure 10248
• N-Linked / Complex / Structure 923
• N-Linked / Complex / Structure 10229
• N-Linked / Complex / Structure 10166
• N-Linked / Complex / Structure 10283
• N-Linked / Complex / Structure 10305
• N-Linked / Complex / NeuAc(?2-?)Gal(?1-?)GlcNAc(?1-?)Man(a1-3)[NeuAc(?2-?)Gal(?1-?)GlcNAc(?1-?)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / Structure 10303
• N-Linked / Complex / Structure 1149
• N-Linked / Complex / Structure 10203
• N-Linked / Complex / Structure 10231
• N-Linked / Complex / Structure 10146
• N-Linked / Complex / Structure 10198
• N-Linked / Complex / Structure 10288
• N-Linked / Complex / Neu?c(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[Neu?c(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Structure 1519
• N-Linked / Complex / Structure 10275
• N-Linked / Complex / Structure 2089
• N-Linked / Complex / Structure 10151
• N-Linked / Complex / Structure 10155
• N-Linked / Complex / Structure 10251
• N-Linked / Complex / Structure 10296
• N-Linked / Complex / Structure 10225
• N-Linked / Complex / Gal(?1-?)GlcNAc(?1-?)[Gal(?1-?)GlcNAc(?1-?)]Man(a1-3)[Gal(?1-?)GlcNAc(?1-?)[Gal(?1-?)GlcNAc(?1-?)]Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Structure 10123
• N-Linked / Complex / Structure 10217
• N-Linked / Complex / Structure 350
• N-Linked / Complex / Structure 10170
• N-Linked / Complex / Structure 10173
• N-Linked / Complex / Structure 10249
• N-Linked / Complex / Structure 10278
• N-Linked / Complex / Structure 10179
• N-Linked / Complex / Structure 1712
• N-Linked / Complex / Structure 10232
• N-Linked / Complex / Structure 138
• N-Linked / Complex / Structure 10158
• N-Linked / Complex / Structure 10247
• N-Linked / Complex / Structure 10156
• N-Linked / Complex / Structure 10171
• N-Linked / Complex / Structure 10308
• N-Linked / Complex / Structure 10137
• N-Linked / Complex / Structure 10182
• N-Linked / Complex / Structure 1342
• N-Linked / Complex / Structure 10149
• N-Linked / Complex / Structure 10193
• N-Linked / Complex / Structure 10243
• N-Linked / High-Mannose / Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc+"+ Man"
• N-Linked / High-Mannose / Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / High-Mannose / Structure 3374
• N-Linked / High-Mannose / Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / High-Mannose / Structure 2601
• N-Linked / High-Mannose / Structure 3485
• N-Linked / High-Mannose / Structure 10138
• N-Linked / High-Mannose / Structure 314
• N-Linked / High-Mannose / Structure 3572
• N-Linked / High-Mannose / Structure 10291
• N-Linked / High-Mannose / Structure 2364
• N-Linked / High-Mannose / Structure 2636
• N-Linked / High-Mannose / Structure 10300
• N-Linked / High-Mannose / Structure 3677
• N-Linked / High-Mannose / Structure 10029
• N-Linked / Hybrid / Structure 1713
• N-Linked / Hybrid / Structure 10205
• N-Linked / Hybrid / Structure 10267
• N-Linked / Hybrid / Structure 10178
• N-Linked / Hybrid / Structure 10252
• N-Linked / No-core / Man(a1-?)Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / No-core / Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(a1-3)[Man(a1-2)Man(a1-6)]Man(b1-4)GlcNAc
• N-Linked / Pauci-Mannose / Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Pauci-Mannose / Structure 1786
• N-Linked / Pauci-Mannose / Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc+"+ GlcNAc"

Composition

• Hex:2 HexNAc:2 (avg mass : 748.6901 )
• Hex:3 HexNAc:2 (avg mass : 910.8325 )
• Hex:3 HexNAc:3 (avg mass : 1114.0275 )
• Hex:3 HexNAc:3 dHex:1 (avg mass : 1260.1705 )
• Hex:3 HexNAc:4 dHex:1 (avg mass : 1463.3655 )
• Hex:3 HexNAc:5 dHex:1 (avg mass : 1666.5605 )
• Hex:3 HexNAc:6 dHex:1 (avg mass : 1869.7555 )
• Hex:3 HexNAc:6 dHex:2 (avg mass : 2015.8985 )
• Hex:4 HexNAc:2 (avg mass : 1072.9749 )
• Hex:4 HexNAc:3 (avg mass : 1276.1699 )
• Hex:4 HexNAc:3 dHex:1 (avg mass : 1422.3129 )
• Hex:4 HexNAc:4 (avg mass : 1479.3649 )
• Hex:4 HexNAc:4 dHex:1 (avg mass : 1625.5079 )
• Hex:4 HexNAc:5 dHex:1 (avg mass : 1828.7029 )
• Hex:4 HexNAc:5 dHex:1 NeuAc:1 (avg mass : 2119.9608 )
• Hex:4 HexNAc:5 dHex:2 (avg mass : 1974.8459 )
• Hex:5 HexNAc:2 (avg mass : 1235.1173 )
• Hex:5 HexNAc:3 (avg mass : 1438.3123 )
• Hex:5 HexNAc:3 dHex:1 (avg mass : 1584.4553 )
• Hex:5 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 1875.7132 )
• Hex:5 HexNAc:4 (avg mass : 1641.5073 )
• Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )
• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:5 HexNAc:4 dHex:1 (avg mass : 1787.6503 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
• Hex:5 HexNAc:5 (avg mass : 1844.7023 )
• Hex:5 HexNAc:5 NeuAc:1 (avg mass : 2135.9602 )
• Hex:5 HexNAc:5 dHex:1 (avg mass : 1990.8453 )
• Hex:5 HexNAc:5 dHex:1 NeuAc:1 (avg mass : 2282.1032 )
• Hex:5 HexNAc:5 dHex:1 NeuAc:2 (avg mass : 2573.3611 )
• Hex:5 HexNAc:6 dHex:1 (avg mass : 2194.0403 )
• Hex:5 HexNAc:6 dHex:1 NeuAc:1 (avg mass : 2485.2982 )
• Hex:6 HexNAc:2 (avg mass : 1397.2597 )
• Hex:6 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 2037.8556 )
• Hex:6 HexNAc:5 dHex:1 (avg mass : 2152.9877 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:1 (avg mass : 2444.2456 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:2 (avg mass : 2735.5035 )
• Hex:6 HexNAc:6 dHex:1 (avg mass : 2356.1827 )
• Hex:6 HexNAc:6 dHex:1 NeuAc:1 (avg mass : 2647.4406 )
• Hex:6 HexNAc:6 dHex:1 NeuAc:2 (avg mass : 2938.6985 )
• Hex:6 HexNAc:7 dHex:1 (avg mass : 2559.3777 )
• Hex:6 HexNAc:7 dHex:1 NeuAc:1 (avg mass : 2850.6356 )
• Hex:7 HexNAc:2 (avg mass : 1559.4021 )
• Hex:7 HexNAc:6 dHex:1 (avg mass : 2518.3251 )
• Hex:7 HexNAc:6 dHex:1 NeuAc:1 (avg mass : 2809.583 )
• Hex:7 HexNAc:6 dHex:1 NeuAc:2 (avg mass : 3100.8409 )
• Hex:7 HexNAc:6 dHex:1 NeuAc:3 (avg mass : 3392.0988 )
• Hex:7 HexNAc:7 dHex:1 (avg mass : 2721.5201 )
• Hex:7 HexNAc:7 dHex:1 NeuAc:1 (avg mass : 3012.778 )
• Hex:7 HexNAc:7 dHex:1 NeuAc:2 (avg mass : 3304.0359 )
• Hex:8 HexNAc:2 (avg mass : 1721.5445 )
• Hex:9 HexNAc:2 (avg mass : 1883.6869 )

Disease

• Atopic dermatitis (DOID:3310)
• Control/Healthy
• Hyper IgE syndrome (DOID:0080545)
• Hyperimmune condition
• Hypersensitivity reaction disease (DOID:0060056)
• IgE myeloma (DOID:9538)
• Multiple myeloma (DOID:9538)

Reference

• Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and α-1B-Glycoprotein (2018 - Shisheng Sun, Yingwei Hu, Li Jia, Shadi Toghi Eshghi, Yang Liu, Punit Shah, Hui Zhang) / Status : Unreviewed
• A single glycan on IgE is indispensable for initiation of anaphylaxis (2015 - Kai-Ting C. Shade, Barbara Platzer, Nathaniel Washburn, Vinidhra Mani, Yannic C. Bartsch, Michelle Conroy, Jose D. Pagan, Carlos Bosques, Thorsten R. Mempel, Edda Fiebiger, Robert M. Anthony) / Status : Reviewed
• Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels, (2014 - Atfa Sassi, Sandra Lazaroski, Gang Wu, Stuart M. Haslam, Manfred Fliegauf, Fethi Mellouli, Turkan Patiroglu, Ekrem Unal, Mehmet Akif Ozdemir, Zineb Jouhadi, Khadija Khadir, Leila Ben-Khemis, Meriem Ben-Ali, Imen Ben-Mustapha, Lamia Borchani, Dietmar Pfeifer, Thilo Jakob, Monia Khemiri, A. Charlotta Asplund, Manuela O. Gustafsson, Karin E. Lundin, Elin Falk-Sörqvist, Lotte N. Moens, Hatice Eke Gungor, Karin R. Engelhardt, Magdalena Dziadzio, Hans Stauss, Bernhard Fleckenstein, Rebecca Meier, Khairunnadiya Prayitno, Andrea Maul-Pavicic, Sandra Schaffer, Mirzokhid Rakhmanov, Philipp Henneke, Helene Kraus, Hermann Eibel, Uwe Kölsch, Sellama Nadifi, Mats Nilsson, Mohamed Bejaoui, Alejandro A. Schäffer, C.I. Edvard Smith, Anne Dell, Mohamed-Ridha Barbouche, Bodo Grimbacher) / Status : Reviewed
• Site-specific N-glycosylation analysis of human immunoglobulin E. (2014 - Plomp R, Hensbergen PJ, Rombouts Y, Zauner G, Dragan I, Koeleman CA, Deelder AM, Wuhrer M) / Status : Reviewed
• The Glycosylation of Human Serum IgD and IgE and the Accessibility of Identified Oligomannose Structures for Interaction with Mannan-Binding Lectin (2004 - James N. Arnold, Catherine M. Radcliffe, Mark R. Wormald, Louise Royle, David J. Harvey, Max Crispin, Raymond A. Dwek, Robert B. Sim and Pauline M. Rudd) / Status : Reviewed
• Structure of the carbohydrate units of IgE immunoglobulin. I. Over-all composition, glycopeptide isolation, and structure of the high mannose oligosaccharide unit. (1974 - Baenziger J, Kornfeld S, Kochwa S) / Status : Reviewed
• Structure of the carbohydrate units of IgE immunoglobulin. II. Sequence of the sialic acid-containing glycopeptides. (1974 - Baenziger J, Kornfeld S, Kochwa S) / Status : Reviewed

Reported glycosite

• Immunoglobulin epsilon chain c region / Homo sapiens
  •        Undefined site
  •        Asn-21
  •        Asn-49
  •        Asn-99
  •        Asn-146
  •        Asn-252
  •        Asn-264
  •        Asn-275

Mass spectrometry observed peptide

• NGTLTVTSTLPVGTR (15aa)
  •    P01854    Asn-275     Immunoglobulin epsilon chain c region / Homo sapiens