Heavy Chain Disease

Taxonomy

• Homo sapiens (Human)

Protein

• Immunoglobulin heavy constant gamma 1 / Homo sapiens    P01857

Source

• Urine (UBERON_0001088)  

Reported structure

• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)Man(a1-6)[Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)Man(a1-6)[GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:4 HexNAc:3 (avg mass : 1276.1699 )
• Hex:4 HexNAc:4 (avg mass : 1479.3649 )
• Hex:5 HexNAc:4 (avg mass : 1641.5073 )

Disease

• Heavy Chain Disease (DOID:0060125)

Reference

• Comparative structural study of the N-linked oligosaccharides of human normal and pathological immunoglobulin G. (1987 - Takahashi N, Ishii I, Ishihara H, Mori M, Tejima S, Jefferis R, Endo S, Arata Y) / Status : Reviewed

Reported glycosite

• Immunoglobulin heavy constant gamma 1 / Homo sapiens
  •        Asn-180

Mass spectrometry observed peptide