GlyConnect

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Site	Core / Type	Cartoon	Composition	Biological associations
Asn-275	N-Linked / Pauci-Mannose		Hex:3 HexNAc:2	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (3) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source Blood Serum (UBERON_0001977) Reported structure N-Linked / Pauci-Mannose / Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc Composition Hex:3 HexNAc:2 (avg mass : 910.8325 ) Disease Hyperimmune condition IgE myeloma (DOID:9538) Multiple myeloma (DOID:9538) Reference Site-specific N-glycosylation analysis of human immunoglobulin E. (2014 - Plomp R, Hensbergen PJ, Rombouts Y, Zauner G, Dragan I, Koeleman CA, Deelder AM, Wuhrer M) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide
Asn-275	N-Linked / High-Mannose		Hex:7 HexNAc:2	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (0) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source HEK293T (CVCL_0063) Reported structure N-Linked / High-Mannose / Structure 314 Composition Hex:7 HexNAc:2 (avg mass : 1559.4021 ) Disease Reference A single glycan on IgE is indispensable for initiation of anaphylaxis (2015 - Kai-Ting C. Shade, Barbara Platzer, Nathaniel Washburn, Vinidhra Mani, Yannic C. Bartsch, Michelle Conroy, Jose D. Pagan, Carlos Bosques, Thorsten R. Mempel, Edda Fiebiger, Robert M. Anthony) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide
Asn-275	N-Linked / High-Mannose		Hex:5 HexNAc:2	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (0) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source HEK293T (CVCL_0063) Reported structure N-Linked / High-Mannose / Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc Composition Hex:5 HexNAc:2 (avg mass : 1235.1173 ) Disease Reference A single glycan on IgE is indispensable for initiation of anaphylaxis (2015 - Kai-Ting C. Shade, Barbara Platzer, Nathaniel Washburn, Vinidhra Mani, Yannic C. Bartsch, Michelle Conroy, Jose D. Pagan, Carlos Bosques, Thorsten R. Mempel, Edda Fiebiger, Robert M. Anthony) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide
Asn-275	N-Linked / Hybrid		Hex:5 HexNAc:3	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (0) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source HEK293T (CVCL_0063) Reported structure N-Linked / Hybrid / Structure 1713 Composition Hex:5 HexNAc:3 (avg mass : 1438.3123 ) Disease Reference A single glycan on IgE is indispensable for initiation of anaphylaxis (2015 - Kai-Ting C. Shade, Barbara Platzer, Nathaniel Washburn, Vinidhra Mani, Yannic C. Bartsch, Michelle Conroy, Jose D. Pagan, Carlos Bosques, Thorsten R. Mempel, Edda Fiebiger, Robert M. Anthony) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide
Asn-275	N-Linked / No-core		Hex:2 HexNAc:2	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (1) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source Blood Serum (UBERON_0001977) Reported structure N-Linked / No-core / Man(a1-?)Man(b1-4)GlcNAc(b1-4)GlcNAc Composition Hex:2 HexNAc:2 (avg mass : 748.6901 ) Disease Hyperimmune condition Reference Site-specific N-glycosylation analysis of human immunoglobulin E. (2014 - Plomp R, Hensbergen PJ, Rombouts Y, Zauner G, Dragan I, Koeleman CA, Deelder AM, Wuhrer M) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide
Asn-275	N-Linked / Pauci-Mannose		Hex:4 HexNAc:2	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (3) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source Blood Serum (UBERON_0001977) Reported structure N-Linked / Pauci-Mannose / Structure 1786 Composition Hex:4 HexNAc:2 (avg mass : 1072.9749 ) Disease Hyperimmune condition IgE myeloma (DOID:9538) Multiple myeloma (DOID:9538) Reference Site-specific N-glycosylation analysis of human immunoglobulin E. (2014 - Plomp R, Hensbergen PJ, Rombouts Y, Zauner G, Dragan I, Koeleman CA, Deelder AM, Wuhrer M) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide
Asn-275	N-Linked / High-Mannose		Hex:8 HexNAc:2	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (4) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source Blood Serum (UBERON_0001977) Reported structure N-Linked / High-Mannose / Structure 2364 Composition Hex:8 HexNAc:2 (avg mass : 1721.5445 ) Disease Control/Healthy Hyperimmune condition IgE myeloma (DOID:9538) Multiple myeloma (DOID:9538) Reference Site-specific N-glycosylation analysis of human immunoglobulin E. (2014 - Plomp R, Hensbergen PJ, Rombouts Y, Zauner G, Dragan I, Koeleman CA, Deelder AM, Wuhrer M) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide
Asn-275	N-Linked / High-Mannose		Hex:6 HexNAc:2	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (4) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source Blood Serum (UBERON_0001977) Reported structure N-Linked / High-Mannose / Structure 2601 Composition Hex:6 HexNAc:2 (avg mass : 1397.2597 ) Disease Control/Healthy Hyperimmune condition IgE myeloma (DOID:9538) Multiple myeloma (DOID:9538) Reference Site-specific N-glycosylation analysis of human immunoglobulin E. (2014 - Plomp R, Hensbergen PJ, Rombouts Y, Zauner G, Dragan I, Koeleman CA, Deelder AM, Wuhrer M) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide
Asn-275	N-Linked / High-Mannose		Hex:8 HexNAc:2	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (0) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source HEK293T (CVCL_0063) Reported structure N-Linked / High-Mannose / Structure 2636 Composition Hex:8 HexNAc:2 (avg mass : 1721.5445 ) Disease Reference A single glycan on IgE is indispensable for initiation of anaphylaxis (2015 - Kai-Ting C. Shade, Barbara Platzer, Nathaniel Washburn, Vinidhra Mani, Yannic C. Bartsch, Michelle Conroy, Jose D. Pagan, Carlos Bosques, Thorsten R. Mempel, Edda Fiebiger, Robert M. Anthony) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide
Asn-275	N-Linked / Undefined core		Hex:5 HexNAc:2	taxonomy (1) protein (1) source (1) structure (0) composition (1) disease (0) reference (1) site (1) peptide (1) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source Blood Serum (UBERON_0001977) Reported structure Composition Hex:5 HexNAc:2 (avg mass : 1235.1173 ) Disease Reference Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and α-1B-Glycoprotein (2018 - Shisheng Sun, Yingwei Hu, Li Jia, Shadi Toghi Eshghi, Yang Liu, Punit Shah, Hui Zhang) / Status : Unreviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide NGTLTVTSTLPVGTR (15aa) P01854 Asn-275 Immunoglobulin epsilon chain c region / Homo sapiens
Asn-275	N-Linked / High-Mannose		Hex:5 HexNAc:2	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (4) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source Blood Serum (UBERON_0001977) Reported structure N-Linked / High-Mannose / Structure 3374 Composition Hex:5 HexNAc:2 (avg mass : 1235.1173 ) Disease Control/Healthy Hyperimmune condition IgE myeloma (DOID:9538) Multiple myeloma (DOID:9538) Reference Site-specific N-glycosylation analysis of human immunoglobulin E. (2014 - Plomp R, Hensbergen PJ, Rombouts Y, Zauner G, Dragan I, Koeleman CA, Deelder AM, Wuhrer M) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide
Asn-275	N-Linked / High-Mannose		Hex:7 HexNAc:2	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (4) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source Blood Serum (UBERON_0001977) Reported structure N-Linked / High-Mannose / Structure 3572 Composition Hex:7 HexNAc:2 (avg mass : 1559.4021 ) Disease Control/Healthy Hyperimmune condition IgE myeloma (DOID:9538) Multiple myeloma (DOID:9538) Reference Site-specific N-glycosylation analysis of human immunoglobulin E. (2014 - Plomp R, Hensbergen PJ, Rombouts Y, Zauner G, Dragan I, Koeleman CA, Deelder AM, Wuhrer M) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide
Asn-275	N-Linked / High-Mannose		Hex:9 HexNAc:2	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (2) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source Blood Serum (UBERON_0001977) Reported structure N-Linked / High-Mannose / Structure 3677 Composition Hex:9 HexNAc:2 (avg mass : 1883.6869 ) Disease Control/Healthy Hyperimmune condition Reference Site-specific N-glycosylation analysis of human immunoglobulin E. (2014 - Plomp R, Hensbergen PJ, Rombouts Y, Zauner G, Dragan I, Koeleman CA, Deelder AM, Wuhrer M) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide
Asn-275	N-Linked / High-Mannose		Hex:6 HexNAc:2	taxonomy (1) protein (1) source (1) structure (1) composition (1) disease (0) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Immunoglobulin epsilon chain c region / Homo sapiens P01854 Source HEK293T (CVCL_0063) Reported structure N-Linked / High-Mannose / Structure 10138 Composition Hex:6 HexNAc:2 (avg mass : 1397.2597 ) Disease Reference A single glycan on IgE is indispensable for initiation of anaphylaxis (2015 - Kai-Ting C. Shade, Barbara Platzer, Nathaniel Washburn, Vinidhra Mani, Yannic C. Bartsch, Michelle Conroy, Jose D. Pagan, Carlos Bosques, Thorsten R. Mempel, Edda Fiebiger, Robert M. Anthony) / Status : Reviewed Reported glycosite Immunoglobulin epsilon chain c region / Homo sapiens Asn-275 Mass spectrometry observed peptide

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